4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors

Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic anti-tumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains unknown whether the impressive effects of CD19 CARs relate to greater susceptibility of h...

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Publicado en:Nat Med
Autores principales: Long, Adrienne H., Haso, Waleed M., Shern, Jack F., Wanhainen, Kelsey M., Murgai, Meera, Ingaramo, Maria, Smith, Jillian P., Walker, Alec J., Kohler, M. Eric, Venkateshwara, Vikas R., Kaplan, Rosandra N., Patterson, George H., Fry, Terry J., Orentas, Rimas J., Mackall, Crystal L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458184/
https://ncbi.nlm.nih.gov/pubmed/25939063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3838
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