4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors

Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic anti-tumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains unknown whether the impressive effects of CD19 CARs relate to greater susceptibility of h...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Long, Adrienne H., Haso, Waleed M., Shern, Jack F., Wanhainen, Kelsey M., Murgai, Meera, Ingaramo, Maria, Smith, Jillian P., Walker, Alec J., Kohler, M. Eric, Venkateshwara, Vikas R., Kaplan, Rosandra N., Patterson, George H., Fry, Terry J., Orentas, Rimas J., Mackall, Crystal L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458184/
https://ncbi.nlm.nih.gov/pubmed/25939063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3838
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