Combined CD28 and 4–1BB costimulation potentiates affinity-tuned Chimeric Antigen Receptor-engineered T cells

PURPOSE: Targeting non-specific, tumor associated antigens (TAA) with chimeric antigen receptors (CARs) requires specific attention to restrict possible detrimental on-target/off-tumor effects. A reduced affinity may direct CAR-engineered T (CAR-T) cells to tumor cells expressing high TAA levels whi...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Drent, Esther, Poels, Renée, Ruiter, Ruud, van de Donk, Niels W.C.J., Zweegman, Sonja, Yuan, Huipin, de Bruijn, Joost, Sadelain, Michel, Lokhorst, Henk M., Groen, Richard W.J., Mutis, Tuna, Themeli, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477921/
https://ncbi.nlm.nih.gov/pubmed/30979735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2559
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