Preclinical and clinical studies for transplant tolerance via the mixed chimerism approach

Based upon observations in murine models, we have developed protocols to induce renal allograft tolerance by combined kidney and bone marrow transplantation (CKBMT) in non-human primates (NHP) and in humans. Induction of persistent mixed chimerism has proved to be extremely difficult in major histoc...

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Bibliographic Details
Published in:Hum Immunol
Main Authors: Sasaki, Hajime, Oura, Tetsu, Spitzer, Thomas R., Chen, Yi-Bin, Madsen, Joren C., Allan, James, Sachs, David H., Cosimi, A.B., Kawai, Tatsuo
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963722/
https://ncbi.nlm.nih.gov/pubmed/29175110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2017.11.008
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