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Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8

The identification of protein ligands from a DNA-encoded library is commonly conducted by an affinity selection assay. These assays are often not validated for robustness, raising questions about selections that fail to identify ligands and the utility of enrichment values for ranking ligand potenci...

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Foilsithe in:SLAS Discov
Main Authors: Denton, Kyle E., Wang, Sijie, Gignac, Michael C., Milosevich, Natalia, Hof, Fraser, Dykhuizen, Emily C., Krusemark, Casey J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962403/
https://ncbi.nlm.nih.gov/pubmed/29309209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555217750871
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