Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family

[Image: see text] The polycomb paralogs CBX2, CBX4, CBX6, CBX7, and CBX8 are epigenetic readers that rely on “aromatic cage” motifs to engage their partners’ methyllysine side chains. Each CBX carries out distinct functions, yet each includes a highly similar methyllysine-reading chromodomain as a k...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Milosevich, Natalia, Gignac, Michael C., McFarlane, James, Simhadri, Chakravarthi, Horvath, Shanti, Daze, Kevin D., Croft, Caitlin S., Dheri, Aman, Quon, Taylor T. H., Douglas, Sarah F., Wulff, Jeremy E., Paci, Irina, Hof, Fraser
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2015
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753544/
https://ncbi.nlm.nih.gov/pubmed/26985288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00378
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