Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family

[Image: see text] The polycomb paralogs CBX2, CBX4, CBX6, CBX7, and CBX8 are epigenetic readers that rely on “aromatic cage” motifs to engage their partners’ methyllysine side chains. Each CBX carries out distinct functions, yet each includes a highly similar methyllysine-reading chromodomain as a k...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Milosevich, Natalia, Gignac, Michael C., McFarlane, James, Simhadri, Chakravarthi, Horvath, Shanti, Daze, Kevin D., Croft, Caitlin S., Dheri, Aman, Quon, Taylor T. H., Douglas, Sarah F., Wulff, Jeremy E., Paci, Irina, Hof, Fraser
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753544/
https://ncbi.nlm.nih.gov/pubmed/26985288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00378
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