Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family

[Image: see text] The polycomb paralogs CBX2, CBX4, CBX6, CBX7, and CBX8 are epigenetic readers that rely on “aromatic cage” motifs to engage their partners’ methyllysine side chains. Each CBX carries out distinct functions, yet each includes a highly similar methyllysine-reading chromodomain as a k...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Milosevich, Natalia, Gignac, Michael C., McFarlane, James, Simhadri, Chakravarthi, Horvath, Shanti, Daze, Kevin D., Croft, Caitlin S., Dheri, Aman, Quon, Taylor T. H., Douglas, Sarah F., Wulff, Jeremy E., Paci, Irina, Hof, Fraser
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753544/
https://ncbi.nlm.nih.gov/pubmed/26985288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00378
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