Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family

[Image: see text] The polycomb paralogs CBX2, CBX4, CBX6, CBX7, and CBX8 are epigenetic readers that rely on “aromatic cage” motifs to engage their partners’ methyllysine side chains. Each CBX carries out distinct functions, yet each includes a highly similar methyllysine-reading chromodomain as a k...

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Publicat a:ACS Med Chem Lett
Autors principals: Milosevich, Natalia, Gignac, Michael C., McFarlane, James, Simhadri, Chakravarthi, Horvath, Shanti, Daze, Kevin D., Croft, Caitlin S., Dheri, Aman, Quon, Taylor T. H., Douglas, Sarah F., Wulff, Jeremy E., Paci, Irina, Hof, Fraser
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753544/
https://ncbi.nlm.nih.gov/pubmed/26985288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00378
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