Optimization of Ligands using Focused DNA-encoded Libraries to Develop a Selective, Cell-permeable CBX8 Chromodomain Inhibitor

Polycomb repressive complex 1 (PRC1) is critical for mediating gene expression during development. Five chromobox (CBX) homolog proteins, CBX2,4,6,7,8, are incorporated into PRC1 complexes, where they mediate targeting to trimethylated lysine 27 of histone H3 (H3K27me3) via the N-terminal chromodoma...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Wang, Sijie, Denton, Kyle E., Hobbs, Kathryn F., Weaver, Tyler, McFarlane, James M. B., Connelly, Katelyn E., Gignac, Michael C., Milosevich, Natalia, Hof, Fraser, Paci, Irina, Musselman, Catherine A., Dykhuizen, Emily C., Krusemark, Casey J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247616/
https://ncbi.nlm.nih.gov/pubmed/31755685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00654
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