Optimization of Ligands using Focused DNA-encoded Libraries to Develop a Selective, Cell-permeable CBX8 Chromodomain Inhibitor

Polycomb repressive complex 1 (PRC1) is critical for mediating gene expression during development. Five chromobox (CBX) homolog proteins, CBX2,4,6,7,8, are incorporated into PRC1 complexes, where they mediate targeting to trimethylated lysine 27 of histone H3 (H3K27me3) via the N-terminal chromodoma...

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Publicat a:ACS Chem Biol
Autors principals: Wang, Sijie, Denton, Kyle E., Hobbs, Kathryn F., Weaver, Tyler, McFarlane, James M. B., Connelly, Katelyn E., Gignac, Michael C., Milosevich, Natalia, Hof, Fraser, Paci, Irina, Musselman, Catherine A., Dykhuizen, Emily C., Krusemark, Casey J.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247616/
https://ncbi.nlm.nih.gov/pubmed/31755685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00654
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