Expanding RNA binding specificity and affinity of engineered PUF domains

Specific manipulation of RNA is necessary for the research in biotechnology and medicine. The RNA-binding domains of Pumilio/fem-3 mRNA binding factors (PUF domains) are programmable RNA binding scaffolds used to engineer artificial proteins that specifically modulate RNAs. However, the native PUF d...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Zhao, Yang-Yang, Mao, Miao-Wei, Zhang, Wen-Jing, Wang, Jue, Li, Hai-Tao, Yang, Yi, Wang, Zefeng, Wu, Jia-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961129/
https://ncbi.nlm.nih.gov/pubmed/29490074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky134
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