Specific and Modular Binding Code for Cytosine Recognition in Pumilio/FBF (PUF) RNA-binding Domains

Pumilio/fem-3 mRNA-binding factor (PUF) proteins possess a recognition code for bases A, U, and G, allowing designed RNA sequence specificity of their modular Pumilio (PUM) repeats. However, recognition side chains in a PUM repeat for cytosine are unknown. Here we report identification of a cytosine...

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Detalhes bibliográficos
Main Authors: Dong, Shuyun, Wang, Yang, Cassidy-Amstutz, Caleb, Lu, Gang, Bigler, Rebecca, Jezyk, Mark R., Li, Chunhua, Hall, Traci M. Tanaka, Wang, Zefeng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144504/
https://ncbi.nlm.nih.gov/pubmed/21653694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.244889
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