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KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics

Eg5, a mitotic kinesin, has been a target for anticancer drug development. Clinical trials of small-molecule inhibitors of Eg5 have been stymied by the development of resistance, attributable to mitotic rescue by a different endogenous kinesin, KIF15. Compared with Eg5, relatively little is known ab...

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Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Milic, Bojan, Chakraborty, Anirban, Han, Kyuho, Bassik, Michael C., Block, Steven M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960320/
https://ncbi.nlm.nih.gov/pubmed/29703754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801242115
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