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The Kinesin-12 Kif15 is a processive track-switching tetramer

Kinesin-12 motors are a little studied branch of the kinesin superfamily with the human protein (Kif15) implicated in spindle mechanics and chromosome movement. In this study, we reconstitute full-length hKif15 and its microtubule-targeting factor hTpx2 in vitro to gain insight into the motors mode...

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Autors principals: Drechsler, Hauke, McHugh, Toni, Singleton, Martin R, Carter, Nicholas J, McAinsh, Andrew D
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965211/
https://ncbi.nlm.nih.gov/pubmed/24668168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01724
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