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Kif15 functions as an active mechanical ratchet
Kif15 is a kinesin-12 that contributes critically to bipolar spindle assembly in humans. Here we use force-ramp experiments in an optical trap to probe the mechanics of single Kif15 molecules under hindering or assisting loads and in a variety of nucleotide states. While unloaded Kif15 is establishe...
Enregistré dans:
| Publié dans: | Mol Biol Cell |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Cell Biology
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6080711/ https://ncbi.nlm.nih.gov/pubmed/29771628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-03-0151 |
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