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KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics
Eg5, a mitotic kinesin, has been a target for anticancer drug development. Clinical trials of small-molecule inhibitors of Eg5 have been stymied by the development of resistance, attributable to mitotic rescue by a different endogenous kinesin, KIF15. Compared with Eg5, relatively little is known ab...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5960320/ https://ncbi.nlm.nih.gov/pubmed/29703754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801242115 |
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