Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models. Most synthetic LXR agonists also cause marked hypertriglyceridemia by inducing the expression of sterol regulatory element-binding protein (SREB...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Muse, Evan D., Yu, Shan, Edillor, Chantle R., Tao, Jenhan, Spann, Nathanael J., Troutman, Ty D., Seidman, Jason S., Henke, Adam, Roland, Jason T., Ozeki, Katherine A., Thompson, Bonne M., McDonald, Jeffrey G., Bahadorani, John, Tsimikas, Sotirios, Grossman, Tamar R., Tremblay, Matthew S., Glass, Christopher K.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
主題:
PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960280/
https://ncbi.nlm.nih.gov/pubmed/29632203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714518115
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