Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models. Most synthetic LXR agonists also cause marked hypertriglyceridemia by inducing the expression of sterol regulatory element-binding protein (SREB...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Muse, Evan D., Yu, Shan, Edillor, Chantle R., Tao, Jenhan, Spann, Nathanael J., Troutman, Ty D., Seidman, Jason S., Henke, Adam, Roland, Jason T., Ozeki, Katherine A., Thompson, Bonne M., McDonald, Jeffrey G., Bahadorani, John, Tsimikas, Sotirios, Grossman, Tamar R., Tremblay, Matthew S., Glass, Christopher K.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960280/
https://ncbi.nlm.nih.gov/pubmed/29632203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714518115
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