Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models. Most synthetic LXR agonists also cause marked hypertriglyceridemia by inducing the expression of sterol regulatory element-binding protein (SREB...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Muse, Evan D., Yu, Shan, Edillor, Chantle R., Tao, Jenhan, Spann, Nathanael J., Troutman, Ty D., Seidman, Jason S., Henke, Adam, Roland, Jason T., Ozeki, Katherine A., Thompson, Bonne M., McDonald, Jeffrey G., Bahadorani, John, Tsimikas, Sotirios, Grossman, Tamar R., Tremblay, Matthew S., Glass, Christopher K.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960280/
https://ncbi.nlm.nih.gov/pubmed/29632203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714518115
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