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Unified approach for extrapolation and bridging of adult information in early-phase dose-finding paediatric studies

The number of trials conducted and the number of patients per trial are typically small in paediatric clinical studies. This is due to ethical constraints and the complexity of the medical process for treating children. While incorporating prior knowledge from adults may be extremely valuable, this...

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Bibliografski detalji
Izdano u:Stat Methods Med Res
Glavni autori: Petit, Caroline, Samson, Adeline, Morita, Satoshi, Ursino, Moreno, Guedj, Jérémie, Jullien, Vincent, Comets, Emmanuelle, Zohar, Sarah
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958415/
https://ncbi.nlm.nih.gov/pubmed/27705884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280216671348
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