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Dose‐finding methods for Phase I clinical trials using pharmacokinetics in small populations

The aim of phase I clinical trials is to obtain reliable information on safety, tolerability, pharmacokinetics (PK), and mechanism of action of drugs with the objective of determining the maximum tolerated dose (MTD). In most phase I studies, dose‐finding and PK analysis are done separately and no a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biom J
Hauptverfasser: Ursino, Moreno, Zohar, Sarah, Lentz, Frederike, Alberti, Corinne, Friede, Tim, Stallard, Nigel, Comets, Emmanuelle
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573988/
https://ncbi.nlm.nih.gov/pubmed/28321893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201600084
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