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Dose‐finding methods for Phase I clinical trials using pharmacokinetics in small populations
The aim of phase I clinical trials is to obtain reliable information on safety, tolerability, pharmacokinetics (PK), and mechanism of action of drugs with the objective of determining the maximum tolerated dose (MTD). In most phase I studies, dose‐finding and PK analysis are done separately and no a...
Guardat en:
| Publicat a: | Biom J |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5573988/ https://ncbi.nlm.nih.gov/pubmed/28321893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201600084 |
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