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Unified approach for extrapolation and bridging of adult information in early-phase dose-finding paediatric studies

The number of trials conducted and the number of patients per trial are typically small in paediatric clinical studies. This is due to ethical constraints and the complexity of the medical process for treating children. While incorporating prior knowledge from adults may be extremely valuable, this...

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Bibliografiske detaljer
Udgivet i:Stat Methods Med Res
Main Authors: Petit, Caroline, Samson, Adeline, Morita, Satoshi, Ursino, Moreno, Guedj, Jérémie, Jullien, Vincent, Comets, Emmanuelle, Zohar, Sarah
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958415/
https://ncbi.nlm.nih.gov/pubmed/27705884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280216671348
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