T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Colony-stimulating factor 1 (CSF1) is a key regulator of monocyte/macrophage differentiation that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). We show that CSF1 is expressed in human melanoma, and patients with metastatic melanoma have increased CSF1 in blood compare...

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Foilsithe in:Sci Transl Med
Main Authors: Neubert, Natalie J., Schmittnaegel, Martina, Bordry, Natacha, Nassiri, Sina, Wald, Noémie, Martignier, Christophe, Tillé, Laure, Homicsko, Krisztian, Damsky, William, Maby-El Hajjami, Hélène, Klaman, Irina, Danenberg, Esther, Ioannidou, Kalliopi, Kandalaft, Lana, Coukos, George, Hoves, Sabine, Ries, Carola H., Fuertes Marraco, Silvia A., Foukas, Periklis G., De Palma, Michele, Speiser, Daniel E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957531/
https://ncbi.nlm.nih.gov/pubmed/29643229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan3311
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