Clarification of the Risk of Chronic Obstructive Pulmonary Disease in α(1)-Antitrypsin Deficiency PiMZ Heterozygotes

Rationale: Severe α(1)-antitrypsin deficiency (typically PiZZ homozygosity) is associated with a significantly increased risk of airflow obstruction and emphysema but the risk of chronic obstructive pulmonary disease (COPD) in PiMZ heterozygotes remains uncertain. Objectives: This was a family-based...

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Udgivet i:Am J Respir Crit Care Med
Main Authors: Molloy, Kevin, Hersh, Craig P., Morris, Valerie B., Carroll, Tomás P., O’Connor, Catherine A., Lasky-Su, Jessica A., Greene, Catherine M., O’Neill, Shane J., Silverman, Edwin K., McElvaney, Noel G.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955067/
https://ncbi.nlm.nih.gov/pubmed/24428606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201311-1984OC
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