Selenoprotein S/SEPS1 Modifies Endoplasmic Reticulum Stress in Z Variant α(1)-Antitrypsin Deficiency

Z α(1)-antitrypsin (ZAAT) deficiency is a disease associated with emphysematous lung disease and also with liver disease. The liver disease of AAT deficiency is associated with endoplasmic reticulum (ER) stress. SEPS1 is a selenoprotein that, through a chaperone activity, decreases ER stress. To det...

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Bibliografiske detaljer
Main Authors: Kelly, Emer, Greene, Catherine M., Carroll, Tomás P., McElvaney, Noel G., O'Neill, Shane J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719325/
https://ncbi.nlm.nih.gov/pubmed/19398551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006288
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