DNP-Enhanced MAS NMR: A Tool to Snapshot Conformational Ensembles of α-Synuclein in Different States

Intrinsically disordered proteins dynamically sample a wide conformational space and therefore do not adopt a stable and defined three-dimensional conformation. The structural heterogeneity is related to their proper functioning in physiological processes. Knowledge of the conformational ensemble is...

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Detalhes bibliográficos
Publicado no:Biophys J
Principais autores: Uluca, Boran, Viennet, Thibault, Petrović, Dušan, Shaykhalishahi, Hamed, Weirich, Franziska, Gönülalan, Ayşenur, Strodel, Birgit, Etzkorn, Manuel, Hoyer, Wolfgang, Heise, Henrike
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2018
Assuntos:
Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954275/
https://ncbi.nlm.nih.gov/pubmed/29642031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.02.011
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