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Molecular-level secondary structure, polymorphism, and dynamics of full-length α-synuclein fibrils studied by solid-state NMR

The 140-residue protein α-synuclein (AS) is able to form amyloid fibrils and as such is the main component of protein inclusions involved in Parkinson's disease. We have investigated the structure and dynamics of full-length AS fibrils by high-resolution solid-state NMR spectroscopy. Homonuclea...

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Bibliografski detalji
Glavni autori: Heise, Henrike, Hoyer, Wolfgang, Becker, Stefan, Andronesi, Ovidiu C., Riedel, Dietmar, Baldus, Marc
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276071/
https://ncbi.nlm.nih.gov/pubmed/16247008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506109102
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