Solid-State NMR Structure of a Pathogenic Fibril of Full-Length Human α-Synuclein

Misfolded α-synuclein amyloid fibrils are the principal components of Lewy bodies and neurites, hallmarks of Parkinson’s disease (PD). Here we present a high-resolution structure of an α-synuclein fibril, in a form that induces robust pathology in primary neuronal culture, determined by solid-state...

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I publikationen:Nat Struct Mol Biol
Huvudupphovsmän: Tuttle, Marcus D., Comellas, Gemma, Nieuwkoop, Andrew J., Covell, Dustin J., Berthold, Deborah A., Kloepper, Kathryn D., Courtney, Joseph M., Kim, Jae K., Barclay, Alexander M., Kendall, Amy, Wan, William, Stubbs, Gerald, Schwieters, Charles D., Lee, Virginia M. Y., George, Julia M., Rienstra, Chad M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034296/
https://ncbi.nlm.nih.gov/pubmed/27018801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3194
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