Structured regions of α-synuclein fibrils include the early-onset Parkinson’s disease mutation sites

α-Synuclein (AS) fibrils are the major component of Lewy bodies, the pathological hallmark of Parkinson’s disease (PD). Here, we use results from an extensive investigation employing solid-state NMR to present a detailed structural characterization and conformational dynamics quantification of full-...

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Detalhes bibliográficos
Main Authors: Comellas, Gemma, Lemkau, Luisel R., Nieuwkoop, Andrew J., Kloepper, Kathryn D., Ladror, Daniel T., Ebisu, Reika, Woods, Wendy S., Lipton, Andrew S., George, Julia M., Rienstra, Chad M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157309/
https://ncbi.nlm.nih.gov/pubmed/21718702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.06.026
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