Site-Specific Perturbations of Alpha-Synuclein Fibril Structure by the Parkinson's Disease Associated Mutations A53T and E46K

Parkinson's disease (PD) is pathologically characterized by the presence of Lewy bodies (LBs) in dopaminergic neurons of the substantia nigra. These intracellular inclusions are largely composed of misfolded α-synuclein (AS), a neuronal protein that is abundant in the vertebrate brain. Point mu...

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Bibliographic Details
Main Authors: Lemkau, Luisel R., Comellas, Gemma, Lee, Shin W., Rikardsen, Lars K., Woods, Wendy S., George, Julia M., Rienstra, Chad M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591419/
https://ncbi.nlm.nih.gov/pubmed/23505409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049750
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