Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core

Amyloid deposits formed from islet amyloid polypeptide (IAPP) are a hallmark of type 2 diabetes mellitus and are known to be cytotoxic to pancreatic β-cells. The molecular structure of the fibrillar form of IAPP is subject of intense research, and to date, different models exist. We present results...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Weirich, Franziska, Gremer, Lothar, Mirecka, Ewa A., Schiefer, Stephanie, Hoyer, Wolfgang, Heise, Henrike
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015977/
https://ncbi.nlm.nih.gov/pubmed/27607147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161243
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