Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived β-Sheet Fibrils

[Image: see text] Determining the structural origins of amyloid fibrillation is essential for understanding both the pathology of amyloidosis and the rational design of inhibitors to prevent or reverse amyloid formation. In this work, the decisive roles of peptide structures on amyloid self-assembly...

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Detalhes bibliográficos
Publicado no:ACS Nano
Main Authors: Wang, Shih-Ting, Lin, Yiyang, Spencer, Ryan K., Thomas, Michael R., Nguyen, Andy I., Amdursky, Nadav, Pashuck, E. Thomas, Skaalure, Stacey C., Song, Cheng Yu, Parmar, Paresh A., Morgan, Rhodri M., Ercius, Peter, Aloni, Shaul, Zuckermann, Ronald N., Stevens, Molly M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618150/
https://ncbi.nlm.nih.gov/pubmed/28771324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.7b02325
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