Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation

The protein α-Synuclein (αS) is linked to Parkinson’s disease through its abnormal aggregation, which is thought to involve cytosolic and membrane-bound forms of αS. Following previous studies using micelles and vesicles, we present a comprehensive study of αS interaction with phospholipid bilayer n...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Commun Biol
Prif Awduron: Viennet, Thibault, Wördehoff, Michael M., Uluca, Boran, Poojari, Chetan, Shaykhalishahi, Hamed, Willbold, Dieter, Strodel, Birgit, Heise, Henrike, Buell, Alexander K., Hoyer, Wolfgang, Etzkorn, Manuel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123806/
https://ncbi.nlm.nih.gov/pubmed/30271927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0049-z
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