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The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition

Transcription factor-induced reprogramming of somatic cells to pluripotency is mediated via profound alterations in the epigenetic landscape. The histone variant macroH2A1 (mH2A1) is a barrier to the cellular reprogramming process. We demonstrate here that mH2A1 blocks reprogramming and contributes...

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Bibliografiska uppgifter
I publikationen:Mol Cell Biol
Huvudupphovsmän: Pliatska, Maria, Kapasa, Maria, Kokkalis, Antonis, Polyzos, Alexander, Thanos, Dimitris
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2018
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954199/
https://ncbi.nlm.nih.gov/pubmed/29483300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00669-17
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