MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

The chromatin template imposes an epigenetic barrier during the process of somatic cell reprogramming. Here, using fibroblasts derived from macroH2A double knockout mice we show that these histone variants act cooperatively as a barrier to induced pluripotency. Through manipulation of macroH2A isofo...

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Autors principals: Gaspar-Maia, Alexandre, Qadeer, Zulekha A., Hasson, Dan, Ratnakumar, Kajan, Leu, N. Adrian, Leroy, Gary, Liu, Shichong, Costanzi, Carl, Valle-Garcia, David, Schaniel, Christoph, Lemischka, Ihor, Garcia, Benjamin, Pehrson, John R., Bernstein, Emily
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055026/
https://ncbi.nlm.nih.gov/pubmed/23463008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2582
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