Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection

Recombination in HIV-1 is well documented, but its importance in the low-diversity setting of within-host diversification is less understood. Here we develop a novel computational tool (RAPR (Recombination Analysis PRogram)) to enable a detailed view of in vivo viral recombination during early infec...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Song, Hongshuo, Giorgi, Elena E., Ganusov, Vitaly V., Cai, Fangping, Athreya, Gayathri, Yoon, Hyejin, Carja, Oana, Hora, Bhavna, Hraber, Peter, Romero-Severson, Ethan, Jiang, Chunlai, Li, Xiaojun, Wang, Shuyi, Li, Hui, Salazar-Gonzalez, Jesus F., Salazar, Maria G., Goonetilleke, Nilu, Keele, Brandon F., Montefiori, David C., Cohen, Myron S., Shaw, George M., Hahn, Beatrice H., McMichael, Andrew J., Haynes, Barton F., Korber, Bette, Bhattacharya, Tanmoy, Gao, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954121/
https://ncbi.nlm.nih.gov/pubmed/29765018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04217-5
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