Glycoengineering HIV-1 Env creates ‘supercharged’ and ‘hybrid’ glycans to increase neutralizing antibody potency, breadth and saturation

The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and avoid clashes with others. To investigate how Env glycan maturation regul...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Crooks, Ema T., Grimley, Samantha L., Cully, Michelle, Osawa, Keiko, Dekkers, Gillian, Saunders, Kevin, Rämisch, Sebastian, Menis, Sergey, Schief, William R., Doria-Rose, Nicole, Haynes, Barton, Murrell, Ben, Cale, Evan Mitchel, Pegu, Amarendra, Mascola, John R., Vidarsson, Gestur, Binley, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951585/
https://ncbi.nlm.nih.gov/pubmed/29718999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007024
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