Glycoengineering HIV-1 Env creates ‘supercharged’ and ‘hybrid’ glycans to increase neutralizing antibody potency, breadth and saturation

The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and avoid clashes with others. To investigate how Env glycan maturation regul...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Crooks, Ema T., Grimley, Samantha L., Cully, Michelle, Osawa, Keiko, Dekkers, Gillian, Saunders, Kevin, Rämisch, Sebastian, Menis, Sergey, Schief, William R., Doria-Rose, Nicole, Haynes, Barton, Murrell, Ben, Cale, Evan Mitchel, Pegu, Amarendra, Mascola, John R., Vidarsson, Gestur, Binley, James M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951585/
https://ncbi.nlm.nih.gov/pubmed/29718999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007024
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