Glycoengineering HIV-1 Env creates ‘supercharged’ and ‘hybrid’ glycans to increase neutralizing antibody potency, breadth and saturation

The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb). Consequently, most bnAbs must inevitably make some glycan contacts and avoid clashes with others. To investigate how Env glycan maturation regul...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Crooks, Ema T., Grimley, Samantha L., Cully, Michelle, Osawa, Keiko, Dekkers, Gillian, Saunders, Kevin, Rämisch, Sebastian, Menis, Sergey, Schief, William R., Doria-Rose, Nicole, Haynes, Barton, Murrell, Ben, Cale, Evan Mitchel, Pegu, Amarendra, Mascola, John R., Vidarsson, Gestur, Binley, James M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951585/
https://ncbi.nlm.nih.gov/pubmed/29718999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007024
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi