Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

Neutralizing antibodies elicited by HIV-1 coevolve with viral Envs in distinctive patterns, in some cases acquiring substantial breadth. Here we show that primary HIV-1 Envs, when expressed by simian-human immunodeficiency viruses in rhesus macaques, elicited patterns of Env-antibody coevolution str...

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Udgivet i:Science
Main Authors: Roark, Ryan S., Li, Hui, Williams, Wilton B., Chug, Hema, Mason, Rosemarie D., Gorman, Jason, Wang, Shuyi, Lee, Fang-Hua, Rando, Juliette, Bonsignori, Mattia, Hwang, Kwan-Ki, Saunders, Kevin O., Wiehe, Kevin, Moody, M. Anthony, Hraber, Peter T., Wagh, Kshitij, Giorgi, Elena E., Russell, Ronnie M., Bibollet-Ruche, Frederic, Liu, Weimin, Connell, Jesse, Smith, Andrew G., DeVoto, Julia, Murphy, Alexander I., Smith, Jessica, Ding, Wenge, Zhao, Chengyan, Chohan, Neha, Okumura, Maho, Rosario, Christina, Ding, Yu, Lindemuth, Emily, Bauer, Anya M., Bar, Katharine J., Ambrozak, David, Chao, Cara W., Chuang, Gwo-Yu, Geng, Hui, Lin, Bob C., Louder, Mark K., Nguyen, Richard, Zhang, Baoshan, Lewis, Mark G., Raymond, Donald D., Doria-Rose, Nicole A., Schramm, Chaim A., Douek, Daniel C., Roederer, Mario, Kepler, Thomas B., Kelsoe, Garnett, Mascola, John R., Kwong, Peter D., Korber, Bette T., Harrison, Stephen C., Haynes, Barton F., Hahn, Beatrice H., Shaw, George M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040783/
https://ncbi.nlm.nih.gov/pubmed/33214287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd2638
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