HIV-1 Virus-Like Particles Bearing Pure Env Trimers Expose Neutralizing Epitopes but Occlude Nonneutralizing Epitopes

Hypothetically, since native HIV-1 Env trimers are exclusively recognized by neutralizing antibodies, they might induce the neutralizing antibodies in a vaccine setting. This idea has not been evaluated due to the difficulty of separating trimers from nonfunctional Env (uncleaved gp160 and gp41 stum...

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Hlavní autoři: Tong, Tommy, Crooks, Ema T., Osawa, Keiko, Binley, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302546/
https://ncbi.nlm.nih.gov/pubmed/22301141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06938-11
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