Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability

Double cyclization of short linear peptides obtained by solid phase peptide synthesis was used to prepare bridged bicyclic peptides (BBPs) corresponding to the topology of bridged bicyclic alkanes such as norbornane. Diastereomeric norbornapeptides were investigated by (1)H-NMR, X-ray crystallograph...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Chem Sci
Hoofdauteurs: Bartoloni, Marco, Jin, Xian, Marcaida, Maria José, Banha, João, Dibonaventura, Ivan, Bongoni, Swathi, Bartho, Kathrin, Gräbner, Olivia, Sefkow, Michael, Darbre, Tamis, Reymond, Jean-Louis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Royal Society of Chemistry 2015
Onderwerpen:
Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949603/
https://ncbi.nlm.nih.gov/pubmed/29861888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01699a
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items