Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms

Herein we report the discovery of antimicrobial bridged bicyclic peptides (AMBPs) active against Pseudomonas aeruginosa, a highly problematic Gram negative bacterium in the hospital environment. Two of these AMBPs show strong biofilm inhibition and dispersal activity and enhance the activity of poly...

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Veröffentlicht in:Chem Sci
Hauptverfasser: Di Bonaventura, Ivan, Jin, Xian, Visini, Ricardo, Probst, Daniel, Javor, Sacha, Gan, Bee-Ha, Michaud, Gaëlle, Natalello, Antonino, Doglia, Silvia Maria, Köhler, Thilo, van Delden, Christian, Stocker, Achim, Darbre, Tamis, Reymond, Jean-Louis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2017
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643981/
https://ncbi.nlm.nih.gov/pubmed/29147502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc01314k
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