Design, crystal structure and atomic force microscopy study of thioether ligated d,l-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa

Here we report a new family of cyclic antimicrobial peptides (CAMPs) targeting MDR strains of Pseudomonas aeruginosa. These CAMPs are cyclized via a xylene double thioether bridge connecting two cysteines placed at the ends of a linear amphiphilic alternating d,l-sequence composed of lysines and try...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: He, Runze, Di Bonaventura, Ivan, Visini, Ricardo, Gan, Bee-Ha, Fu, Yongchun, Probst, Daniel, Lüscher, Alexandre, Köhler, Thilo, van Delden, Christian, Stocker, Achim, Hong, Wenjing, Darbre, Tamis, Reymond, Jean-Louis
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676089/
https://ncbi.nlm.nih.gov/pubmed/29163899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc01599b
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