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The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar eff...
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| Publicado no: | Chem Commun (Camb) |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society of Chemistry
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8186529/ https://ncbi.nlm.nih.gov/pubmed/33972964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1cc01838h |
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