Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa

Colistin (polymyxin E) is a last-resort antibiotic against multidrug-resistant isolates of Pseudomonas aeruginosa. However, the nephro-toxicity of colistin limits its use, spurring the interest in novel antimicrobial peptides (AMP). Here, we show that the synthetic AMP-dendrimer G3KL (MW 4,531.38 Da...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Ben Jeddou, Fatma, Falconnet, Léna, Luscher, Alexandre, Siriwardena, Thissa, Reymond, Jean-Louis, van Delden, Christian, Köhler, Thilo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179292/
https://ncbi.nlm.nih.gov/pubmed/32015046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02040-19
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