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Peptide Dendrimer/Lipid Hybrid Systems Are Efficient DNA Transfection Reagents: Structure–Activity Relationships Highlight the Role of Charge Distribution Across Dendrimer Generations

[Image: see text] Efficient DNA delivery into cells is the prerequisite of the genetic manipulation of organisms in molecular and cellular biology as well as, ultimately, in nonviral gene therapy. Current reagents, however, are relatively inefficient, and structure–activity relationships to guide th...

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Main Authors: Kwok, Albert, Eggimann, Gabriela A., Reymond, Jean-Louis, Darbre, Tamis, Hollfelder, Florian
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715887/
https://ncbi.nlm.nih.gov/pubmed/23682947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn400343z
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