Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes

The function of medullary thymic epithelial cells (mTECs) is associated with thymocyte adhesion, which is crucial for the negative selection of autoreactive thymocytes in the thymus. This process represents the root of central tolerance of self-components and prevents the onset of autoimmune disease...

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Опубликовано в: :Front Immunol
Главные авторы: Speck-Hernandez, Cesar A., Assis, Amanda F., Felicio, Rafaela F., Cotrim-Sousa, Larissa, Pezzi, Nicole, Lopes, Gabriel S., Bombonato-Prado, Karina F., Giuliatti, Silvana, Passos, Geraldo A.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949327/
https://ncbi.nlm.nih.gov/pubmed/29867946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00964
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