Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes

The function of medullary thymic epithelial cells (mTECs) is associated with thymocyte adhesion, which is crucial for the negative selection of autoreactive thymocytes in the thymus. This process represents the root of central tolerance of self-components and prevents the onset of autoimmune disease...

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Publicat a:Front Immunol
Autors principals: Speck-Hernandez, Cesar A., Assis, Amanda F., Felicio, Rafaela F., Cotrim-Sousa, Larissa, Pezzi, Nicole, Lopes, Gabriel S., Bombonato-Prado, Karina F., Giuliatti, Silvana, Passos, Geraldo A.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949327/
https://ncbi.nlm.nih.gov/pubmed/29867946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00964
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