Serum-free Erythroid Differentiation for Efficient Genetic Modification and High-Level Adult Hemoglobin Production

In vitro erythroid differentiation from primary human cells is valuable to develop genetic strategies for hemoglobin disorders. However, current erythroid differentiation methods are encumbered by modest transduction rates and high baseline fetal hemoglobin production. In this study, we sought to im...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Ther Methods Clin Dev
Prif Awduron: Uchida, Naoya, Demirci, Selami, Haro-Mora, Juan J., Fujita, Atsushi, Raines, Lydia N., Hsieh, Matthew M., Tisdale, John F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Gene & Cell Therapy 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948232/
https://ncbi.nlm.nih.gov/pubmed/29766032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.03.007
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