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Efficient generation of β-globin-expressing erythroid cells using stromal cell-derived induced pluripotent stem cells from patients with sickle cell disease

Human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent an ideal source for in vitro modeling of erythropoiesis and a potential alternative source for red blood cell transfusions. However, iPS cell-derived erythroid cells predominantly produce ε- and γ-globin without β-glo...

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Foilsithe in:Stem Cells
Main Authors: Uchida, Naoya, Haro-Mora, Juan J., Fujita, Atsushi, Lee, Duck-Yeon, Winkler, Thomas, Hsieh, Matthew M., Tisdale, John F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330841/
https://ncbi.nlm.nih.gov/pubmed/27739611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2517
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